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Type 2 Diabetes – What could be affecting your level of HbA1c?
Type 2 diabetes should have the A1C test performed, the level of HbA1c indicates that the average level of blood sugar were within two or three months. If you did not do this test every three to six months, you should talk to your doctor. glycated hemoglobin, HbA1c for short, is used to assess glycemic control, because it gives a longer period at a level of sugar in the blood taken on any given morning.
Hemoglobin is a molecule in red blood cells. This is the molecule that carries oxygen throughout the body. Red blood cells live about 120 days, in order to measure glucose levels of hemoglobin, we can get a picture of what your blood sugar has been for about three months.
hemoglobin molecules different: more molecules of human hemoglobin are the same, but the hemoglobin molecule is large, and some people have hemoglobin molecules that are slightly different from this kind of habit. The molecule is composed of amino acids and iron ions. There are over 20 types of amino acids, and sometimes a person is born with a different amino acid instead of a custom. This substitution causes sickle cell anemia …
* While the normal human hemoglobin HbA is reduced, the sickle cell hemoglobin is HbS shortened.
If a normal hemoglobin molecule is an amino acid called glutamic acid among its many amino acids, a molecule of hemoglobin in sickle cell anemia is another amino acid, valine, in the same position. Another variant is HbF, a hemoglobin molecule is the same hemoglobin by the fetus, but sometimes seen in adults. In this variant, it is more than one amino acid substitution. Variants such as HbS and HbF are called hemoglobinopathies.
Hemoglobinopaties: According to research conducted at the Department of Biochemistry and Clinical Chemistry, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka, testing for HbA1c in patients with HbS or HbF may give false results. The results of their study were published in September 2010 in the Journal of Southeast Asian tropical medicine and public health. Two thousand 695 patients with diabetes were tested for hemoglobinopathies. Two percent were found to have HbF or HbS. HbA1c in patients with normal hemoglobin are a better indication of blood sugar that the same measures in patients with hemoglobinopathies HbF or HbS. The researchers found that diabetics with HbA1c levels, which do not appear to be correlated with fasting glucose should be tested for hemoglobinopathies.
The frequency of haemoglobinopathies are highly variable in different populations. A study in southern Turkey is located in hemoglobin S:
* 3.9 per cent of the total population
* 9.6 percent among those in Arabic, while
* No one was observed among the Kurds.
Another study in Brazil showed 14 percent of the population in some regions with the stroke, while in other regions there were no porters.
If the fasting glucose always tell a story different from the results of the HbA1c test, consider the possibility of a hemoglobinopathy with your doctor.
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